Cellular Reprograming
Cellular reprogramming is an emerging field in biomedicine that explores approaches to alter age‑associated cellular states.
​
Biomolecular Herbology offers a complementary avenue by providing natural compounds that may modulate pathways involved in cellular aging. Phytochemicals such as polyphenols, flavonoids, and terpenes, found in various medicinal herbs, have been shown in experimental studies to influence transcription factors and gene expression patterns associated with aging.​
Pluripotency Enhancement Formula
This Formula is designed to boost the expression of key pluripotency transcription factors such as Oct4, Sox2, and Nanog.
By activating these factors, the formula supports efficient cellular reprogramming, enabling differentiated cells to revert to a pluripotent state.
Mechanism of Action:
-
Activation of Pluripotency Genes: Enhances the expression of genes critical for maintaining pluripotency.
-
Modulation of Signaling Pathways: Influences pathways like SIRT1/AMPK, PI3K/Akt, and Wnt/β-catenin to promote a cellular environment conducive to reprogramming.
-
Antioxidant Support: Provides antioxidant protection to reduce oxidative stress during the reprogramming process.
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Epigenetic Reset Formula
The Epigenetic Reset Formula aims to modify and reset the epigenetic landscape of cells, including DNA methylation patterns and histone modifications. By altering these epigenetic marks, the formula facilitates cellular reprogramming and promotes a more youthful gene expression profile.
Mechanism of Action:
-
DNA Methylation Modulation: Adjusts the activity of DNA methyltransferases and demethylases to reset aberrant methylation patterns.
-
Histone Modification: Influences histone acetyltransferases and deacetylases to alter chromatin structure and gene accessibility.
-
Pathway Regulation: Targets key signaling pathways such as PI3K/Akt, TGF-β/Smad, and MAPK/ERK involved in epigenetic regulation.
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Stem Cell Maintenance and Differentiation Formula
This formulation supports the maintenance of stem cells and promotes their differentiation into various tissue types. By enhancing stem cell function, it aids in tissue repair and regeneration.
Mechanism of Action:
-
Support of Self-Renewal: Activates signaling pathways that maintain stem cells in an undifferentiated state, such as SIRT1 and cAMP/PKA.
-
Promotion of Differentiation: Modulates pathways like PI3K/Akt, TGF-β, and MAPK/ERK to guide stem cells into specific lineages.
-
Enhancement of Stem Cell Viability: Protects stem cells from apoptosis and oxidative stress.
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Mitochondrial Biogenesis and Energy Formula
The goal of this formula is to enhance mitochondrial function and energy production, which are vital for cellular health and longevity. Healthy mitochondria provide the energy required for effective cellular reprogramming and function.
Mechanism of Action:
-
Activation of Mitochondrial Biogenesis: Stimulates pathways that increase the number and efficiency of mitochondria, such as SIRT1/AMPK and cAMP/PKA.
-
Energy Metabolism Enhancement: Improves ATP production and metabolic efficiency.
-
Protection Against Oxidative Stress: Protects mitochondrial integrity by reducing oxidative damage.
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
DNA Protection and Cellular Longevity Formula
The DNA Protection and Cellular Longevity Formula is designed to safeguard DNA from damage and support longevity by enhancing cellular resilience and repair mechanisms.
​
Mechanism of Action:
-
Telomere Maintenance: Activates telomerase to preserve telomere length, delaying cellular senescence.
-
Enhancement of DNA Repair: Upregulates DNA repair enzymes and pathways to maintain genomic integrity.
-
Antioxidant Defense: Provides comprehensive antioxidant protection to reduce oxidative DNA damage.
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Yamanaka Factors Optimization Formula
Beyond the original four Yamanaka factors, researchers are exploring modified or alternative combinations of factors to optimize reprogramming for specific purposes, such as avoiding oncogenic risks associated with c-MYC or finding safer reprogramming protocols that balance efficiency and safety for therapeutic use. What are the 7 best hebs from the worlds medicas including TCM, Western herbology, Ayurvedic and Siddhi that can facilitate this process?
Optimizing the Yamanaka factors for cellular reprogramming involves exploring safer and more efficient methods, such as minimizing oncogenic risks (e.g., those associated with c-MYC) and improving the balance between cellular rejuvenation and stability. Herbs that support cellular protection, DNA repair, epigenetic modulation, and safe regeneration are crucial for this approach
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Anti-Inflammatory Cellular Repair Formula
This formula focuses on reducing inflammation to promote a cellular environment conducive to reprogramming and regeneration. Chronic inflammation can hinder cellular repair mechanisms and impair reprogramming efficiency.
​
Mechanism of Action:
-
Inhibition of Inflammatory Pathways: Suppresses key inflammatory mediators like NF-κB, reducing the production of pro-inflammatory cytokines.
-
Antioxidant Activity: Scavenges reactive oxygen species to protect cells from oxidative damage.
-
Promotion of Cellular Repair: Enhances autophagy and supports the removal of damaged cellular components, facilitating regeneration.
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Metabolic Optimization Formula
The Metabolic Optimization Formula focuses on improving cellular metabolism to create an optimal environment for reprogramming and regeneration. Efficient energy production and nutrient sensing are critical for maintaining cellular health and supporting the energy-intensive process of reprogramming cells to a pluripotent state.
​
Mechanism of Action:
-
AMPK Activation:
-
Energy Sensor Enhancement: Activates AMP-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis.
-
Mitochondrial Biogenesis Promotion: Stimulates the production of new mitochondria, enhancing ATP production and cellular energy availability.
-
-
mTOR Pathway Modulation:
-
Anabolic-Catabolic Balance: Inhibits the mechanistic target of rapamycin (mTOR) pathway to promote autophagy and prevent excessive cell growth that can deplete resources.
-
Support of Cellular Repair Processes: Facilitates the removal of damaged proteins and organelles, improving cellular function.
-
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Senescence Reduction and Cellular Rejuvenation Formula
The Senescence Reduction and Cellular Rejuvenation Formula is designed to eliminate senescent cells and promote a youthful cellular environment. Senescent cells are aged or damaged cells that have ceased to divide but remain metabolically active, often secreting pro-inflammatory factors that impair tissue function and inhibit regeneration. By targeting these cells and reducing their negative impact, this formula enhances tissue health and supports effective cellular reprogramming.
​
Mechanism of Action:
-
Senolytic Activity:
-
Selective Clearance of Senescent Cells: The formula promotes apoptosis (programmed cell death) specifically in senescent cells without harming healthy cells.
-
Reduction of Senescence-Associated Secretory Phenotype (SASP): Decreases the secretion of pro-inflammatory cytokines, chemokines, and proteases that contribute to chronic inflammation and tissue dysfunction.
-
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Proteostasis Enhancement and Autophagy Support Formula
The Proteostasis Enhancement and Autophagy Support Formula is formulated to help support protein homeostasis within cells. Proper folding, processing, and clearance of proteins are essential for normal cellular function. Accumulation of misfolded or aggregated proteins can impair cellular processes. By supporting proteostasis and autophagy pathways, this formula may help maintain cellular integrity and function.
​
Mechanism of Action:
-
Heat shock protein induction — may support molecular chaperone activity and help reduce accumulation of misfolded proteins.
-
Enhancement of autophagy — may support autophagic flux and assist cellular clearance of protein aggregates and dysfunctional organelles.
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
*None of these statements have been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Disclaimer: The entire contents of this website are the opinion of Extended Longevity, Inc. They are not intended to replace a one-on-one relationship with a qualified health care professional, and they are not intended as medical advice. They are intended as a sharing of knowledge and information from the research and experience of Extended Longevity, Inc. Intelligent Remedies, Inc. encourages you to make your own health care decisions based on your research and in partnership with a qualified health care professional.
All material provided from Extended Longevity, Inc. is for informational or educational purposes only. Consult a physician regarding the applicability of any opinions or recommendations with respect to your symptoms or medical condition. The instructions and advice presented from Extended Longevity, Inc. are in no way intended as medical advice or a substitute for medical counseling. The information should be used in conjunction with the guidance and care of your physician. Consult your physician before taking any Extended Longevity, Inc. products. Your physician should be aware of all medical conditions you may have, as well as medications and supplements you are taking. If you are on diuretics or diabetes medication, have liver or gallbladder disease, take medications, or have other health concerns, please proceed only under a doctor’s supervision.