To understand what makes the Extended Longevity protocol unique, it's helpful to know some recent history about the aging research field. In August 2019, Dr. Steven Horvath from UCLA announced a major study. Dr. Horvath is known for creating the epigenetic clock, which is the most accurate way to measure biological age, more so than just counting calendar years.
The study was part of the TRIM project led by Dr. Fahey. It involved a small group of people and tested whether a mix of drugs and minerals (like Metformin, HGH, DHEA, Zinc, and Selenium) could reverse thymic aging (thymic involution). The study was successful. Dr. Fahey had extra blood samples from the participants and sent them to Dr. Horvath. The results showed that the epigenetic clock could be turned back, but only by about 2.5 years. This was a major breakthrough because it was the first time anyone had shown that biological aging could be reversed using this method.
This discovery sparked new excitement in the aging research field. It also inspired our company to develop natural, side-effect-free compounds that mimic these drugs, which could be used as herbal medicines.
We further studied important research, including the “Hallmarks of Aging,” which identifies 10 main causes of aging. I’ve reinterpreted these causes to include the epigenetic clock, cellular aging, telomeres, blood signals, NAD levels, the pineal gland's clock, stem cell and thymus regeneration, extracellular matrix stiffening, and chronic inflammation (called inflammaging). We believe these are the key factors driving the aging process.
Our formulas have been shown to improve key markers of aging. For example, testing of our CEO, Steven M. Schorr, showed his biological age is 51.8, a 15-year reduction—much better than the 2.5-year improvement in the earlier study.
We also observed that his telomeres are longer than those of a new-born, which helps prevent cell aging and inflammation. Additionally, his C-reactive protein (a measure of inflammation) dropped to levels of a 15-year-old, and his thymus appeared to regenerate, with healthy T-cell levels like a young person.
All these results are based on data, and while we don’t claim to cure diseases, they show significant signs of slowed aging.
There is now a broad scientific consensus that aging is primarily a degenerative process that is controlled by time-sequenced internal biological clocks, whose effects are felt as we age, across the human organism, and by systemic and cellular reactions to internal conditions.
Our research has determined that aging is largely controlled by ten (10) primary internal biological factors, now understood to be reversible. Here they are listed hierarchically, most important to least important:
Pineal clock- (Pineal / Hypothalmic/ Pituitary/ Superchiasmatic Nucleolus (SCN) axis) this is the master time clock and coordinates the body's circadian rhythm and the time-cycled release of melatonin and other critical hormones and neurotransmitters.
Thymic involution- immune depletion, and T-cell diminution.
Blood signaling and transcription factors- reverse distributed blood signaling of TGF-ß1 and Oxytocin (to all cells).
Telomere length- Attrition of the protective chromosomal endcaps causing programmed Cellular senescence.
Senolytics- (autophagy, mitophagy) Accumulation of senescent zombie-like cells that inflame and signal senescence to healthy cells.
Inflammaging- Inflammatory response, altered intercellular communication and the production of inflammatory cytokine and chemokine molecules.
Stem Cell Exhaustion- loss of source stem cells.
Cellular Metabolic Efficiency (NAD, NMN, NR, Sirtuins, Resveratrol, ATP, ROS)- Energy production and mitochondrial dysfunction.
Epigenetic clock (DNAm cytosine methylation)- Alterations to the epigenome that control which genes are turned on and off.
Extra Cellular Matrix Stiffening - The decrease in elastin, in turn, increases collagen content and ECM stiffness. This causes age-related diseases such as hypertension, and atherosclerosis.
• Two factors are endocrinological: Pineal/ Hypothalamic /Pituitary/ SCN axis, and Thymus involution, which are internal aging-clock related.
• Two factors are DNA based: Telomere length and Epigenetic DNA methylation, which are internal aging-clock related.
• Two factors are cellular: Cellular Metabolic Efficiency and Senolytics, and are adapted systemic responses.
• Four factors are Systemic: Blood signaling, Extra Cellular Matrix Stiffening, and Stem Cell Exhaustion, which are internal aging-clock related and Inflammaging, which is an adapted systemic response.
In order to address these conditions of aging Extended Longevity has developed ten (10) synergistic and mimetic biologic formulations. They include:
1. Pinetonal™ - is a Pineal Gland supporting formulation of six (6) plant species known to increase melatonin, pineol, zinc, and selenium, included are phytotherapeutic extracts of Pistacia vera, Scutellaria baicalensis, Passiflora incarnata, Panax quinquefolius, Elitaria cardamomum, and Cinnamomum verum.
2. Thyvolve™ - is designed for regenerating the Thymus Gland and reversing the age-dependent process of Thymus involution. It consists of six (6) phytotherapeutic extracts including Selaginella involvens, Pinus sylvestris (Pollen), Curcuma longa, Zingiber officinale, Elitaria cardamomum, and Cinnamomum verum.
3. Bluecosig™ - Bluecosig Formula is designed for blood signaling and transcription adjustment, for aging reversal or rejuvenation via blood signaling to all cells. It contains phytotherapeutic extracts of Caulophyllum thalictroides, Panax quinquefolius, Scutellaria baicalensis, and Curcuma longa.
4. Telogenic™ - Telogenic Longevity Formula is a phytotherapeutic extract of three (3) synergistic herbal analogs, including Astragalus membranaceus, Centella asiatica, and Salix Alba. It is a telomerase-creating natural plant extract that stops the degradation of telomeres and rebuilds them, reversing cell loss from telomere attrition.
5. Sentophagy™ - is a phytotherapeutic extraction of five (5) plant species known to induce autophagy and mitophagy, including Taraxacum officinale, Camellia senensis, Berberis vulgarus, Curcuma longa, and Cinnamomum verum.
6. Inflasolve™ - is formulated to reduce systemic inflammation that is a root cause of aging (called “Inflammaging”). It contains phytotherapeutic extracts of Curcuma longa, Boswellia sacra, Salix alba, Camellia sinensis, and Cinnamomum verum.
7. Stemegenis™ - is designed to regenerate active stem cells from the age-dependent condition called “stem cell exhaustion,” reversing it. It contains phytotherapeutic extracts of Garcinia indica, Astragalus membracanus, and Cinnamomum verum.
8. CMEnhance™ - is designed to support Cellular Metabolic Efficiency, increasing Resveratrol, Sirtuins, NAD, NMN and contains phytotherapeutic extracts of Polygonum cuspidatum, Scutellaria baicalensis, Tabebuia avellanedae, Curcuma longa, and Cinnamomum verum.
9. Epiverse™ - is an Epigenetic Clock reversing (DNAm, cytosine methylation) synergistic herbal analog formulation of six (6) plant species. Included are phytotherapeutic extracts of Berberis vulgaris, Pinus sylvestris (Pollen), Lepidium meyenii, Taraxacum officinale, Elitaria cardamomum, and Cinnamomum verum.
10. Elastage ECM™- is designed to stimulate the growth of elastin and strengthen the flexibility of the Extra Cellular Matrix. Elastic fibers, composed of an elastin core (90%) surrounded by fibrillin-richmicrofibrils (10%), endow tissues with critical mechanical properties such as resilience, flexibility, and elasticity.
Rejuvenation and the reversal of the aging process is a slow, steady process that requires patience and perseverance, like watching grass grow. In some instances, there will be remarkable transformations. Otherwise, as it has taken many years to ripen our physical maturity, so it will rejuvenate in the fullness of time.