This is the master time clock and coordinates the body's circadian rhythm and the time-cycled release of melatonin and other critical hormones and neurotransmitters.

The Thymus Gland transitions to adipose fat from age 30 to the late 60's causing immune depletion, and T-cell diminution.

Blood signaling is the method whereby cells receive information from the master physiological clocks. Reverse distributed blood signaling of TGF-ß1 and Oxytocin (to all cells) signals rejuvenation.

Telomeres get shorter with each cell division. Attrition of the protective chromosomal endcaps cause programmed Cellular senescence.

Accumulation of senescent zombie-like cells that inflame and signal senescence to healthy cells.

Inflammatory response, altered intercellular communication and the production of inflammatory cytokine and chemokine molecules.

Stem cells exhaust over time in response to metabolic stress. This leads to a loss of regenerative source stem cells.

Mitochondria are the energy producing organelles of cellular metabolism. Energy production and mitochondrial dysfunction.

Alterations to the epigenome that control which genes are turned on and off.

The decrease in elastin, in turn, increases collagen content and ECM stiffness. This causes age-related diseases such as hypertension, and

atherosclerosis.