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The Extended Longevity Protocol

Core Products

Our research shows that aging is controlled by ten reversible internal biological factors.

Below, you'll find these factors listed alongside their corresponding products.

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Brain issues medical concept. Photo of female doctor, empty space. .jpg

Pineal clock

 

The pineal‑hypothalamic‑pituitary‑SCN axis helps regulate circadian rhythms and the normal release of melatonin and other hormones.

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Supporting natural melatonin production may help maintain healthy pineal function and normal sleep–wake cycles that can change with age.

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Imbalances in pineal signaling may affect circadian regulation and sleep patterns; these formulations are intended to support healthy circadian function and overall sleep quality.

Pinetonal™

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This formulation combines botanicals and minerals that may help support natural sleep patterns and a healthy sleep-wake cycle.*

 

Pistachio extract, Baikal skullcap, passionflower, American ginseng, cardamom, Ceylon cinnamon, zinc, and selenium.

PINETONAL product logo by Extended Longevity
Longevity, Pinetonal

Thymic involution

 

Beginning around age 30, the thymus typically undergoes gradual shrinkage (involution).

 

Over time much of the gland is commonly replaced by fat, and this age‑related change is associated with shifts in T‑cell production and immune system functioning

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Thyvolve

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This formula is intended to support healthy thymus function and age‑associated immune resiliency.

 

It combines six phytotherapeutic extracts Selaginella involvens, Scots pine pollen, turmeric, ginger, cardamom, and Ceylon cinnamon

THYVOLVE product logo by Extended Longevity
Thyvolve
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Blood Signaling and Transcription

 

Research involving heterochronic parabiosis (connecting a young and old animal to share blood circulation)

 

Early studies revealed that age-related signaling molecules in the blood instruct the body's 100 trillion cells to age.*

 

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Bluecosig

 

Bluecosig Formula is formulated to support healthy cellular communication and metabolic signaling associated with aging.

 

It features phytotherapeutic extracts of blue cohosh, fenugreek, American ginseng, Baikal skullcap, and turmeric, which may help support normal cellular function and systemic wellness.

BLUECOSIG product logo by Extended Longevity

Inflammaging

Inflammation is the body’s normal defense response to harmful stimuli.

 

With age, immune regulation can change, and many people experience low‑grade, chronic inflammation that may contribute to tissue changes and age‑associated health concerns — A phenomenon often called "inflammaging."

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Inflasolve™

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Formulated to support healthy inflammatory balance 

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This formulation combines phytotherapeutic extracts of turmeric, frankincense, white willow bark, green tea, and Ceylon cinnamon— selected to help support healthy inflammatory balance and cellular resiliency associated with aging.

INFLASOLVE product logo by Extended Longevity

Epigenetic clock

 

Epigenetics refers to modifications of DNA, RNA, or proteins that regulate these molecules without altering their primary sequence.

 

Influenced by genetics, lifestyle, diet, and environment, these modifications affect gene behavior.

 

Read the white paper below to learn how external factors may lead to changes in DNA‑associated structure and affect gene regulation.*

Epiverse

 

Epiverse is a synergistic herbal formulation intended to support healthy epigenetic regulation and cellular resiliency.*

 

This blend combines six phytotherapeutic extracts—barberry, Scots pine pollen, maca root, dandelion, cardamom, and Ceylon cinnamon

EPIVERSE product logo by Extended Longevity

Telomere length

 

Tealomeres are protective caps at the ends of chromosomes.

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At birth, they are at their longest, but with each cell division, they lose some DNA. Over time, repeated cell division and oxidative stress contribute to telomere shortening, which is associated with limits on cellular replication.

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Telomere shortening is linked to cellular aging processes and is one factor associated with changes in tissue function over time.

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Telogenic

 

Featuring 3 synergistic herbal extracts traditionally used to support cellular health

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These botanicals may help support healthy telomere maintenance and cellular resiliency associated with normal aging

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Astragalus, Centella asiatica, and White willow.

TELOGENIC product logo by Extended Longevity

Senolytics

 

Research indicates cellular senescence is associated with age‑related changes in tissue function.

 

In preclinical studies, removing senescent cells has improved certain tissue functions*

 

Senescent cells can secrete pro‑inflammatory factors (the SASP) that influence local and systemic tissue environments and may disrupt normal tissue homeostasis.*

Sentophagy™

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A phytotherapeutic extract composed of five plant species known to promote autophagy and mitophagy.

 

This formulation supports cellular cleansing and rejuvenation by enhancing the body's natural processes for removing damaged cells and organelles. 

 

Taraxacum officinale, Camellia sinensis, Barberry, Curcuma longa, and Ceylon cinnamon

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SENTOPHAGY product logo by Extended Longevity

Extra Cellular Matrix Stiffening

 

The extracellular matrix (ECM) is largely made of collagen and elastin, which provide structural support in tissues.*

 

With age, the balance of ECM components can change—decreased elastin and relative increases in collagen—leading to greater tissue stiffness that can affect cardiovascular and pulmonary function.*

 

The loss of elastin limits the functionality of cardiovascular and pulmonary systems.

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This formula is intended to help support healthy elastin maintenance and extracellular matrix (ECM) resiliency associated with normal tissue function.

 

Elastic fibers (primarily elastin with fibrillin‑rich microfibrils) contribute to tissue elasticity and resilience. Age‑related changes can increase crosslinking of ECM proteins such as collagen and elastin, which may affect tissue mechanics.

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This product includes Paeonia lactiflora, Anethum graveolens, Camellia sinensis, Vitis vinifera (grape), Curcuma longa (turmeric), and Cinnamomum verum.

ELASTAGE product logo by Extended Longevity
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Dramatic Flowers

Stem Cell Exhaustion

 

Decreased renewal of stem cells contributes to age-related disorders. "Stem Cell Exhaustion" results from DNA damage, senescence, and other factors.

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Studying stem cells can provide insights into tissue interactions during aging and may help redirect the aging process.

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This exhaustion plays a crucial role in age-related functional decline.

Stemegenis

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Stemegenis is formulated to regenerate active stem cells impacted by “stem cell exhaustion,” effectively reversing this age-related condition.

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It includes phytotherapeutic extracts of Garcinia indica, astragalus, and Cinnamomum verum

STEMGENIS product logo by Extended Longevity

Cellular Metabolic Efficiency

 

Cellular Metabolic Efficiency (CME) refers to when oxidative stress is low and mitochondria efficiently produce ATP to meet cellular energy needs.

 

Antioxidant availability and bioavailability help support mitochondrial function and reduce metabolic oxidative stress, which can promote sustained cellular energy.

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By supporting metabolic balance and oxidative defenses, these mechanisms may help maintain healthy inflammatory responses and metabolic function associated with aging.

Warm Up on the Beach

CMEnhance

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CMEnhance is formulated to support Cellular Metabolic Efficiency by increasing levels of resveratrol, sirtuins, NAD, and NMN.

 

This blend includes phytotherapeutic extracts of Japanese knotweed, Parsley, Baikal skullcap, Tabebuia avellanedae, Curcuma longa, and Cinnamomum verum 

CME Enhance product logo by Extended Longevity

Benchmark & Measure your results

Start your biological baseline testing:

Epigenome test at Elysium Health

Telomere test at Spectracell

Glycan Age test at Glycan Age

Inflammation test (CRP) Consult local physician

The content on this website is provided by Extended Longevity, Inc. for informational and educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The information reflects the opinions and research of Extended Longevity, Inc. and Intelligent Remedies, Inc., and should not be relied upon as medical advice.

 

Consult your physician or other qualified health care professional before starting any new supplement, diet, or health program, and for information about interactions, contraindications, and individualized medical guidance.

 

Products sold on this site are dietary supplements. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

Do not use if pregnant or nursing without medical supervision. Consult your healthcare provider before use if you are taking prescription medications, have a medical condition (including but not limited to diabetes, liver or gallbladder disease), or are on medications such as diuretics. Keep out of reach of children.

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Adverse events:

If you experience a serious adverse event, discontinue use and contact your healthcare provider immediately. 

 

Privacy & accuracy:

We strive to ensure information is current and accurate but make no warranties about completeness or suitability. Extended Longevity, Inc. is not liable for any direct or indirect damages resulting from use of this site or its products.

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