A Longevity Biotechnology Company
The Extended Longevity protocol
Our research has determined that aging is largely controlled by ten primary internal biological factors, now understood to be reversible. Here they are listed along with their respective products, and the tests available to order for monitoring.
For recommended baseline lab testing go to:
For Epigenome test go to www.elysiumhealth.com/index
For Telomere test go to www.shop.spectracell.com/telomere
For Glycan Age go to: https://glycanage.com/price-and-plans
for C-RP inflammation test consult your local physician.
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Recommended Dosing: Taken orally, 1 ml (one dropper full) of each per day
Nine (9) in the morning before meals and one (1) at night (Pinetonal) before bed, Can be taken under the tongue or with water as desired.
PROBLEM
Pineal clock
(Pineal / Hypothalmic/ Pituitary/ Superchiasmatic Nucleolus (SCN) axis) this is the master time clock and coordinates the body's circadian rhythm and the time-cycled release of melatonin and other critical hormones and neurotransmitters. "Resting" of the Pineal gland function by supplementation of melatonin rejuvenates the Pineal. As we age we produce less and less melatonin. When the pineal gland aging clock breaks down it signals other parts of the body that it is time to age.
SOLUTION
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Formulation of six (6) plant species known to increase melatonin, pineol, zinc, and selenium, included are phytotherapeutic extracts of Pistacia vera, Scutellaria baicalensis, Passiflora incarnata, Panax quinquefolius, Elitaria cardamomum, and Cinnamomum verum
PRODUCT
PROBLEM
Thymic involution
From the age of thirty our Thymus gland, which is responsible for producing immune resistant T-cells, begins to involute and by the age of 65, most of the Thymus has been replaced by adipose fat, with consequent loss of immune function.
Immune depletion, and T-cell diminution.
SOLUTION
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Designed for regenerating the Thymus Gland and reversing the age-dependent process of Thymus involution. It consists of six (6) phytotherapeutic extracts including Selaginella involvens, Pinus sylvestris (Pollen), Curcuma longa, Zingiber officinale, Elitaria cardamomum, and Cinnamomum verum.
PRODUCT
SELF-TESTING
PROBLEM
Blood signaling and transcription
Through experimentation with heterochronic parabiosis, a young and old animal are surgically connected to share a common blood circulation, it was discovered that there were age-related signaling molecules circulating in the blood that told all of the body's 100 trillion cells to age. It was also discovered that this process can be reversed.
SOLUTION
Bluecosig Formula is designed for blood signaling and transcription adjustment, for aging reversal or rejuvenation via blood signaling to all cells. It contains phytotherapeutic extracts of Caulophyllum thalictroides, Trigonella foenum-graecum, Panax quinquefolius, Scutellaria baicalensis, and Curcuma longa.
PRODUCT
SELF-TESTING
PROBLEM
Telomere length
Located at the ends of chromosomes, telomeres protect chromosome ends. When we are born, our telomeres are at their longest. With every cell division throughout the course of our life, our telomeres lose a bit of their DNA. With age and exposure to various sources of oxidative stress, telomeres gradually shorten until the cell cannot replicate. This process acts as an aging clock counting down the remaining life of the cell.
SOLUTION
Phytotherapeutic extract of three (3) synergistic herbal analogs, including Astragalus membranaceus, Centella asiatica, and Salix Alba. They are telomerase-creating natural plant extracts that stop the degradation of telomeres and rebuilds them, reversing cell loss from telomere attrition.
PRODUCT
SELF-TESTING
PROBLEM
Senolytics
Evidence shows the contribution of cellular senescence to age-related tissue dysfunction. Eliminating senescent cells resolves age-related disorders, which may increase lifespan. Because of a senescent associated secretory phenotype (SASP), senescent cells are capable of coordinating distinct non-cell systemic responses that disrupt tissue homeostasis.
SOLUTION
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Phytotherapeutic extraction of five (5) plant species known to induce autophagy and mitophagy, including Taraxacum officinale, Camellia senensis, Berberis vulgarus, Curcuma longa, and Cinnamomum verum.
PRODUCT
SELF-TESTING
PROBLEM
Inflammaging
Inflammation is a defense response of our body to hazardous stimuli. Chronic inflammation, caused by low-grade persistent inflammation, leads to tissue degeneration and is a contributor to various age-related diseases and natural processes in aging tissue. One of the major changes that occur during aging is the dis-regulation of the immune response, leading to a chronic systemic inflammatory state.
SOLUTION
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Formulated to reduce systemic inflammation that is a root cause of aging (called “Inflammaging”). It contains phytotherapeutic extracts of Curcuma longa, Boswellia sacra, Salix alba, Camellia sinensis, and Cinnamomum verum.
PRODUCT
PROBLEM
Stem Cell Exhaustion
The decrease in the renewal of stem cells leads to age-related disorders. “Stem Cell Exhaustion” is a consequence of DNA damage, senescence, and other factors. Stem cells can reveal ways that tissues interact during aging and possibly redirect the fate of aging tissues. Stem cell exhaustion is a key component in the onset of age-related functional decline.
SOLUTION
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Designed to regenerate active stem cells from the age-dependent condition called “stem cell exhaustion,” reversing it. It contains phytotherapeutic extracts of Garcinia indica, Astragalus membracanus, and Cinnamomum verum.
PRODUCT
SELF-TESTING
PROBLEM
Cellular Metabolic Efficiency
When oxidative stress is minimized, Cellular Metabolic Efficiency (CME) is achieved, increasing the efficiency of the cell mitochondria's ATP energy-producing reaction. High antioxidant levels combined with bioavailability are the key to establishing CME, increasing energy, and reducing metabolic oxidative stress at the cellular level. This will also have the effect of reducing inflammation and slowing down the aging process.
SOLUTION
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Designed to support Cellular Metabolic Efficiency, increasing Resveratrol, Sirtuins, NAD, NMN and contains phytotherapeutic extracts of Polygonum cuspidatum, Petroselinum crispum, Scutellaria baicalensis, Tabebuia avellanedae, Curcuma longa, and Cinnamomum verum.
PRODUCT
PROBLEM
Epigenetic clock
Epigenetics refers to the modification of our DNA, RNA, or protein, which can change and regulate these molecules without altering the primary sequence. Our genetics, lifestyle, the food we eat, and the environment we live in, affects these modifications, and therefore affects how our genes behave. Epigenetics can explain how external factors cause the modifications of our DNA and its structures, which results in gene regulation.
SOLUTION
Epigenetic reversing (DNAm, cytosine methylation) synergistic herbal formulation of six (6) plant species. Included are phytotherapeutic extracts of Berberis vulgaris, Pinus sylvestris (Pollen), Lepidium meyenii, Taraxacum officinale, Elitaria cardamomum, and Cinnamomum verum.
PRODUCT
PROBLEM
Extra Cellular Matrix Stiffening
The extracellular matrix is mostly comprised of collagen and elastin. Both proteins are first formed at birth and decrease with time. Any damage that does occur with age and disease is essentially irreparable. The decrease in elastin, in turn, increases collagen content and ECM stiffness. This causes age-related diseases such as hypertension, and atherosclerosis. The decrease in elastin content puts the upper limit on the functioning of cardiovascular
and pulmonary systems and this limit is estimated to be about 100–120 years.
SOLUTION
Elastage ECM is designed to stimulate the growth of elastin and strengthen the flexibility of the Extra Cellular Matrix. Elastic fibers, composed of an elastin core (90%) surrounded by fibrillin-rich
microfibrils (10%), endow tissues with critical mechanical properties such as resilience, flexibility, and elasticity. Aging results from the accumulation of intra-intermolecular crosslinks between molecules with slow turnovers, such as collagen and elastin
PRODUCT
SELF-TESTING
There currently are no available tests on the market. Please check back here for updates.
Extended Longevity enhancement products
In addition to our CORE products, we continue to develop adjunct products that support healthy aging and improve the quality of a long life.
PROBLEM
Immune Enhancement
Osthole the major component of Cnidium exerts a broad spectrum of biological and pharmacological activities. Osthole exhibits immunomodulatory and antiinflammatory properties, by regulating the expression of a series of key factors, involved in the process of immune response and other metabolic and biological processes.
SOLUTION
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The principal action of Cnidium M is to stop the P38 MAPK aging pathway which increase TIM4 thus causing the Macrophages population to increase.
PRODUCT
SELF-TESTING
There currently are no available tests on the market. Please check back here for updates.
PROBLEM
Emotional Regeneration
The amygdala is associated with a range of cognitive functions, including emotion, learning, memory, attention and perception. Current views of amygdala function emphasize its role in negative emotions, such as fear, and in the linking of negative emotions with other aspects of cognition, such as learning and memory.
SOLUTION
The principal action of Emophix is to stimulate the growth of new dendrites in the Amygdala. The purpose of dendritic regeneration in the Amygdala is to allow new neural pathways to be developed in the part of the brain known to control emotions, so as to re-wire the emotional content of the brain by over-writing old hard-wired emotional patterns.
PRODUCT
SELF-TESTING
There currently are no available tests on the market. Please check back here for updates.
PROBLEM
Integrated Stress Response / Brain Regeneration
Consistent with a role for PERK in dictating both protective and pro-apoptotic responses to specific ER insults, imbalances in PERK activity caused by genetic, environmental, or aging-related factors is implicated in the pathogenesis of diverse diseases. Sustained PERK signaling associated with chronic or severe ER insults is implicated in neurodegeneration associated with diseases such as Alzheimer’s disease and prion disease.
SOLUTION
The principal action of Cognilace is in modulating the Integrated Stress Response (ISR) by modulating the PERK pathways that induce the sustained PERK signaling associated with chronic or severe endoplasmic reticulum (ER) insults.
PRODUCT
SELF-TESTING
There currently are no available tests on the market. Please check back here for updates.
PROBLEM
Cartilage Degradation
Cartilage tissue belongs to the family of bradytrophic connective tissues. Due to the unique macro- and microstructural composition and its highly organized structure, cartilage tissue poses a great challenge for researchers who want to repair and regenerate this highly specific tissue. The unique architecture of articular cartilage consists of chondrocytes that produce and are embedded in acartilage-specific, highly organized extracellular matrix (ECM).
The cartilage-specific ECM is not only synthesized by the chondrocytes, as
they are also in close functional interaction with each other and their production in the chondrocytes is stimulated and directly influenced by highly sensitive microenvironmental conditions that stimulate
cartilage homeostasis and repair.
SOLUTION
Effective in promoting cartilage joint regeneration and TE (tissue engineering). It has naturally occurring phytochemical compounds extracted from Curcuma longa, Polygonum Cusputatum, Zingiber officinale, Epimedium grandifolium, Punica granatum, Paeonia lactiflora , Antheum graveolens, and Cinnamomum verum that have anti-inflammatory, anti-oxidant, and anabolic potential for the treatment of inflammatory diseases, including the prevention of age related OA and cartilage TE. It supports cartilage regeneration and TE.
PRODUCT
SELF-TESTING
There currently are no available tests on the market. Please check back here for updates.
PROBLEM
Rebalancing Neurochemistry
Oxytocin acts in many brain areas to recruit local inhibitory circuits. Modulation of inhibitory circuits enables more selective signal enhancement for specific cell types, synapses, and sensory inputs than does the direct excitation of principal cells (Froemke & Schreiner 2015). These observations underscore the importance of examining spontaneous and evoked patterns of synaptic transmission to determine local circuit effects of neuromodulation. There are potentially many biological processes by which oxytocin receptor signaling can indirectly influence gene expression, excitability, synaptic transmission, and neural computations
SOLUTION
Djream contains phytotherapeutic extracts of Trigonella foenum graecum, Nelumbo nucifera, Peganum harmala, Boswellia sacra, Curcuma longa, and Cinnamomium vera. Using advanced laboratory extraction apparatus & proprietary production protocols, these phytochemicals are known for their neuroplasticity and neuromodulated properties which have been observed by changes in excitability, disinhibition, and enabled neuroplasticity.
PRODUCT
SELF-TESTING
There currently are no available tests on the market. Please check back here for updates.