Frequently asked questions

The Extended Longevity protocol is unique because it is based on the latest scientific breakthroughs in the longevity space. Inspired by the groundbreaking TRIM study by Dr. Steven Horvath and Dr. Fahey, which demonstrated the reversal of the epigenetic clock, our protocol uses synergistic and mimetic analogs of pharmaceutical compounds without side effects. We have reinterpreted the ten conditions of aging, including the epigenetic clock, cellular senescence, telomeres, blood signaling, NAD, pineal clock, stem cell regeneration, thymic regeneration, extracellular matrix stiffening, and inflammaging. Our approach combines these insights with herbal medicinal extracts to address the root causes of aging.

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There is now a broad scientific consensus that aging is primarily a degenerative process that is controlled by time-sequenced internal biological clocks, whose effects are felt as we age, across the human organism, and by systemic and cellular reactions to internal conditions. Our research has determined that aging is largely controlled by ten (10) primary internal biological factors, now understood to be reversible. Here they are listed hierarchically, most important to least important: 1. Pineal clock- (Pineal / Hypothalmic/ Pituitary/ Superchiasmatic Nucleolus (SCN) axis) this is the master time clock and coordinates the body's circadian rhythm and the time-cycled release of melatonin and other critical hormones and neurotransmitters. 2. Thymic involution- immune depletion, and T-cell diminution. 3. Blood signaling and transcription factors- reverse distributed blood signaling of TGF-ß1 and Oxytocin (to all cells). 4. Telomere length- Attrition of the protective chromosomal endcaps causing programmed Cellular senescence. 5. Senolytics- (autophagy, mitophagy) Accumulation of senescent zombie-like cells that inflame and signal senescence to healthy cells. 6. Inflammaging- Inflammatory response, altered intercellular communication and the production of inflammatory cytokine and chemokine molecules. 7. Stem Cell Exhaustion- loss of source stem cells. 8. Cellular Metabolic Efficiency (NAD, NMN, NR, Sirtuins, Resveratrol, ATP, ROS)- Energy production and mitochondrial dysfunction. 9. Epigenetic clock (DNAm cytosine methylation)- Alterations to the epigenome that control which genes are turned on and off. 10. Extra Cellular Matrix Stiffening - The decrease in elastin, in turn, increases collagen content and ECM stiffness. This causes age-related diseases such as hypertension, and atherosclerosis. • Two factors are endocrinological: Pineal/ Hypothalamic /Pituitary/ SCN axis, and Thymus involution, which are internal aging-clock related. • Two factors are DNA based: Telomere length and Epigenetic DNA methylation, which are internal aging-clock related. • Two factors are cellular: Cellular Metabolic Efficiency and Senolytics, and are adapted systemic responses. • Four factors are Systemic: Blood signaling, Extra Cellular Matrix Stiffening, and Stem Cell Exhaustion, which are internal aging-clock related and Inflammaging, which is an adapted systemic response. ​ In order to address these conditions of aging Extended Longevity has developed ten (10) synergistic and mimetic biologic formulations. They include: 1. Pinetonal™ - is a Pineal Gland supporting formulation of six (6) plant species known to increase melatonin, pineol, zinc, and selenium, included are phytotherapeutic extracts of Pistacia vera, Scutellaria baicalensis, Passiflora incarnata, Panax quinquefolius, Elitaria cardamomum, and Cinnamomum verum. 2. Thyvolve™ - is designed for regenerating the Thymus Gland and reversing the age-dependent process of Thymus involution. It consists of six (6) phytotherapeutic extracts including Selaginella involvens, Pinus sylvestris (Pollen), Curcuma longa, Zingiber officinale, Elitaria cardamomum, and Cinnamomum verum. 3. Bluecosig™ - Bluecosig Formula is designed for blood signaling and transcription adjustment, for aging reversal or rejuvenation via blood signaling to all cells. It contains phytotherapeutic extracts of Caulophyllum thalictroides, Panax quinquefolius, Scutellaria baicalensis, and Curcuma longa. 4. Telogenic™ - Telogenic Longevity Formula is a phytotherapeutic extract of three (3) synergistic herbal analogs, including Astragalus membranaceus, Centella asiatica, and Salix Alba. It is a telomerase-creating natural plant extract that stops the degradation of telomeres and rebuilds them, reversing cell loss from telomere attrition. 5. Sentophagy™ - is a phytotherapeutic extraction of five (5) plant species known to induce autophagy and mitophagy, including Taraxacum officinale, Camellia senensis, Berberis vulgarus, Curcuma longa, and Cinnamomum verum. 6. Inflasolve™ - is formulated to reduce systemic inflammation that is a root cause of aging (called “Inflammaging”). It contains phytotherapeutic extracts of Curcuma longa, Boswellia sacra, Salix alba, Camellia sinensis, and Cinnamomum verum. 7. Stemegenis™ - is designed to regenerate active stem cells from the age-dependent condition called “stem cell exhaustion,” reversing it. It contains phytotherapeutic extracts of Garcinia indica, Astragalus membracanus, and Cinnamomum verum. 8. CMEnhance™ - is designed to support Cellular Metabolic Efficiency, increasing Resveratrol, Sirtuins, NAD, NMN and contains phytotherapeutic extracts of Polygonum cuspidatum, Scutellaria baicalensis, Tabebuia avellanedae, Curcuma longa, and Cinnamomum verum. 9. Epiverse™ - is an Epigenetic Clock reversing (DNAm, cytosine methylation) synergistic herbal analog formulation of six (6) plant species. Included are phytotherapeutic extracts of Berberis vulgaris, Pinus sylvestris (Pollen), Lepidium meyenii, Taraxacum officinale, Elitaria cardamomum, and Cinnamomum verum. 10. Elastage ECM™- is designed to stimulate the growth of elastin and strengthen the flexibility of the Extra Cellular Matrix. Elastic fibers, composed of an elastin core (90%) surrounded by fibrillin-richmicrofibrils (10%), endow tissues with critical mechanical properties such as resilience, flexibility, and elasticity. ​ Rejuvenation and the reversal of the aging process is a slow, steady process that requires patience and perseverance, like watching grass grow. In some instances, there will be remarkable transformations. Otherwise, as it has taken many years to ripen our physical maturity, so it will rejuvenate in the fullness of time.

The effects of the Extended Longevity products are immediate and considerable. For example, our Inflasolve™ formula is a powerful anti-inflammatory that can ameliorate joint stiffness within hours of consuming. One can also feel the enhanced energy of CMEnhace, which provides energy inducing resveratrol and NAD to the mitochondria. Pinetonal™ assists in enhanced sleep cycles as the melatonin in the formula naturally effects circadian rhythms of the Pineal/ Pituitary/ Hypothalamus/ Super Chiasmatic Nucleus. These effects are visceral! Other effects such as Telogenic’s™ ability to regenerate the telomeres of the chormosomes take time to effect and feel. Similarly, Stemegenis’ ability to regenerate stemcells over the entire 100 trillion cell makeup of the human organism, take time to effect. Thyvolve’s™ ability to regenerate the Thymus gland shows up over time in an increase in T-cells, a measurable phenonium.

Aging is a continuation of a timed growth development program evolving into a phase of late-life self-annihilation. The body adapts to a variety of environmental stresses. These stresses may affect the adaptive responses of specific cellular processes and create resistive strengthening leading to increased longevity. The tendency of the organism to rebalance toward homeostasis is a biological response to both environmental and internal organic conditions that are determined by behavioral processes such as diet, stress, and activity, but can also be affected by certain drugs and/or herbal interventions. The results we are seeing with the Extended Longevity protocol have never been seen before in the modern history of humanity. To say we have cracked to code is an understatement. However, time will tell as to whether we can exist in a stable age-related context or whether we can, in fact, cause rejuvenation and a visceral “youthening” of the organism.