A Longevity Biotechnology Company
Tauopathies are a group of neurodegenerative diseases associated with the pathological aggregation of tau protein in the human brain. Tau is a microtubule-associated protein that plays a crucial role in stabilizing microtubules in nerve cells, which are important for proper neuronal function and for the transport of nutrients and other cellular components. In tauopathies, tau proteins become abnormally phosphorylated and form neurofibrillary tangles, leading to cell death and dysfunction in the brain. The tau protein is primarily associated with microtubule stability in neurons, but it has multiple functions that could contribute to neurodegenerative processes when dysregulated. These functions include axonal transport, cell signaling, and possibly even cell secretion processes. Abnormalities in tau, such as hyperphosphorylation and misfolding, lead to the formation of neurofibrillary tangles, which are hallmarks of these conditions.
Primary tauopathies include conditions such as Alzheimer's disease (AD), which is the most common form of dementia, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease, and others. Secondary tauopathies are those where tau pathology exists alongside other primary neurodegenerative processes.
Phytotherapeutic interventions that rescue pathological tau dysfunction, such as targeting aberrant tau hyperphosphorylation, modulating proteostasis mechanisms, or modulating tau protein translation, hold promise as disease modifying therapies for tauopathies.
Ingredients include:
Huperzine A: Derived from the Chinese club moss Huperzia serrata, it has been shown to improve cognitive function in Alzheimer's patients by increasing neurotransmitter levels. Huperzine A, is suggested to ameliorate memory and learning defects in patients with AD.
2. Glycyrrhiza glaba: has the effects of reducing tau misfolding and reactive oxygen species (ROS) and regulating the expressions of UPR pathway-related genes. These findings indicate the potential role of G. glaba as a novel herb medication for the treatment of AD and tauopathies.
3. Ginkgo Biloba: Contains flavonoids and terpenoids that have antioxidant and anti-inflammatory properties. Studies suggest it may help improve cognitive function and daily living activities in mild Alzheimer's disease.
4. Curcumin: Found in turmeric, curcumin has anti-inflammatory and antioxidant properties. It’s thought to reduce oxidative stress and amyloid pathology in Alzheimer’s disease.
5. Green Tea (Epigallocatechin Gallate, EGCG): The polyphenols in green tea may help to stabilize tau proteins and reduce their misfolding, as shown in some preclinical studies.
6. Lion’s Mane Mushroom (Hericium erinaceus): Has been shown to stimulate nerve growth factor synthesis, potentially aiding in the protection and repair of nerve cells.
7. Bacopa monnieri: An herb traditionally used in Ayurvedic medicine that has shown potential in improving memory and reducing oxidative stress in neurological disorders.